A. Julio Martinez Chair in Neuropathology
Vice Chair of Pathology Faculty Mentorship
Director, Ophthalmic Pathology
Co-Director, Pathologist-Investigator Residency Research Training Program
Professor of Pathology
University of Pittsburgh School of Medicine
Charleen T. Chu, M.D., Ph.D., is Professor of Pathology at the University of Pittsburgh School of Medicine, where she holds the A. Julio Martinez Chair in Neuropathology and serves as Vice-Chair of Pathology Faculty Mentorship, Director of Ophthalmic Pathology and Co-Director of the Pathologist-Investigator Residency Research Training Program. Dr. Chu graduated summa cum laude from Harvard University (AB in Biology), followed by M.D. and Ph.D. (Pathology-Biochemistry) training in the Duke University Medical Scientist Training Program, with residency/fellowship training in Anatomic Pathology and Neuropathology. Dr. Chu runs a multidisciplinary research program focused on the cellular and molecular pathogenesis of Parkinson’s disease, related Lewy body dementias, and primary mitochondrial disorders. Her laboratory studies compartmentalized kinase signaling in neuron cell biology, with an emphasis on mitochondrial quality control in neurons – function, turnover (mitophagy), biogenesis and transport. Recent areas of interest include the neuroprotective potential for targeting autophagy and/or mitochondrial calcium dysregulation in relation to LRRK2- and PINK1-associated pathogenesis.